Free OCR GCSE Combined Science B (Twenty First Century) (J260) Exam Questions and Answers
OCR GCSE Combined Science B (Twenty First Century) (J260) is OCR's GCSE Combined Science B (Twenty First Century) qualification, specification J260, taken in England. It is sat at Foundation or Higher tier. The questions here come from OCR's published question papers from June 2018 to June 2025, plus its specimen papers, with answers and marking guidance taken from OCR's own mark schemes. Written-answer questions let you work out your answer and then reveal what the mark scheme accepts; diagrams, graphs and source material appear with the questions that use them.
Looking for OCR GCSE Combined Science B (Twenty First Century) (J260) exam dumps or ExamTopics questions? These practice questions cover the same ground with verified answers and explanations, a downloadable PDF and a full practice test, kept current as OCR updates the exam.
Last updated: October 15, 2026
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Question #1
The diagrams in the table show different types of cells. Identify the type of cell shown in each diagram. Tick one box in each row. Options: Plant, Animal, Bacterial. Identify the type of cell shown in the first diagram (cell membrane, nucleus, cytoplasm).

Correct answer: B
Explanation
Animal ticked for the first diagram.
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Question #2
The diagrams in the table show different types of cells. Identify the type of cell shown in each diagram. Tick one box in each row. Options: Plant, Animal, Bacterial. Identify the type of cell shown in the second diagram (cell wall, plasmid DNA, chromosomal DNA, cytoplasm).

Correct answer: C
Explanation
Bacterial ticked for the second diagram.
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Question #3
The diagrams in the table show different types of cells. Identify the type of cell shown in each diagram. Tick one box in each row. Options: Plant, Animal, Bacterial. Identify the type of cell shown in the third diagram (cell wall, nucleus, cell membrane, cytoplasm, vacuole, chloroplast).

Correct answer: A
Explanation
Plant ticked for the third diagram.
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Question #4
Hormones control many processes in the human body. Complete the sentences about hormones using words from the list. Each word may be used once, more than once or not at all. blood, glands, nerves, organs, receptors, response, stimuli Hormones enable the body to respond to internal or external ____ . Hormones are secreted by ____ . Hormones are transported by the ____ . Hormones attach to ____ on effectors. This causes a ____ .
Type your answer, then reveal.
Correct answer: stimuli, glands, blood, receptors, response (in order of the blanks)
Explanation
One mark each for: stimuli, glands, blood, receptors, response.
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Question #5
Hormones control many processes in the human body. The menstrual cycle is controlled by hormones. The graph in Fig. 2.1 shows changes in the levels of these hormones during the menstrual cycle when an egg is not fertilised. Look at the graph in Fig. 2.1. Describe how the hormone levels change after an egg has been released.

Type your answer, then reveal.
Correct answer: After the egg is released: oestrogen, FSH and LH levels drop; oestrogen then rises (to a lower peak around day 25) and falls again to a low at day 28; FSH begins to rise again from about day 23; LH stays constant/low; all hormones return to day 0 levels by day 28; progesterone rises then falls.
Explanation
Any three points from: oestrogen, FSH and LH drop; oestrogen then increases to a lower peak around day 25 then decreases to a low at day 28; FSH starts to increase again from about day 23; LH stays constant/low; idea that all hormones return to day 0 levels by day 28; progesterone increases then decreases. Ignore 'all hormone levels drop'.
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Question #6
Contraceptive pills contain hormones that can prevent pregnancy. Which statement gives the best explanation of how the hormones in a contraceptive pill prevent pregnancy? Tick (✓) one box.
Correct answer: C
Explanation
One mark for the correct tick.
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Question #7
Contraceptive pills contain hormones that can prevent pregnancy. Give one disadvantage of relying only on a hormone contraceptive pill to prevent pregnancy.
Type your answer, then reveal.
Correct answer: Hormone pills do not reduce the risk of spreading sexually transmitted infections (STIs).
Explanation
Allow a named STI. Allow the idea of forgetting to take the pill. Ignore 'not 100% effective'.
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Question #8
This question is about the genome. Which two statements about the genome are correct? Tick (✓) two boxes.
Select 2 answers.
Correct answer: A, C
Explanation
One mark for each correct statement.
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Question #9
This question is about the genome. A student makes some notes about genomes. 1. The genome is made from DNA. 2. Genes are sections of DNA. 3. DNA is wound into a triple helix. 4. DNA is a polymer. 5. DNA is made from amino acids. The teacher spots some mistakes. Write down the numbers of the two sentences that contain mistakes. Sentences ____ and ____

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Correct answer: Statements 3 and 5 are incorrect (DNA is a double helix, not a triple helix; DNA is made from nucleotides, not amino acids).
Explanation
3 and 5, in either order, one mark each.
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Question #10
This question is about the genome. The sequence of bases in a whole human genome can be worked out. It cost £1 000 000 000 to sequence a human genome in 2003. It can now be done for £1000. How many times more expensive was it in 2003 than it is now to sequence a human genome? Put a ring around the correct answer in standard form.
Correct answer: C
Explanation
£1 000 000 000 ÷ £1000 = 10⁶.
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Discussion
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