Free AQA GCSE Combined Science: Synergy (8465) Exam Questions and Answers
AQA GCSE Combined Science: Synergy (8465) is AQA's GCSE Combined Science: Synergy qualification, specification 8465, taken in England. It is sat at Foundation or Higher tier. The questions here come from AQA's published question papers from June 2018 to June 2025, plus its specimen papers, with answers and marking guidance taken from AQA's own mark schemes. Written-answer questions let you work out your answer and then reveal what the mark scheme accepts; diagrams, graphs and source material appear with the questions that use them.
Looking for AQA GCSE Combined Science: Synergy (8465) exam dumps or ExamTopics questions? These practice questions cover the same ground with verified answers and explanations, a downloadable PDF and a full practice test, kept current as AQA updates the exam.
Last updated: October 18, 2026
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Question #1
Figure 1 shows a doctor testing a reflex action of a patient. When the doctor touches the patient's foot with a blunt rod, the patient's toes curl. Where are the receptors in this reflex action? Tick (✓) one box.

Correct answer: B
Explanation
One mark for 'in the foot'.
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Question #2
Figure 1 shows a doctor testing a reflex action of a patient. When the doctor touches the patient's foot with a blunt rod, the patient's toes curl. What is the coordinator in this reflex action? Tick (✓) one box.

Correct answer: B
Explanation
One mark for 'the central nervous system'.
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Question #3
Figure 1 shows a doctor testing a reflex action of a patient. When the doctor touches the patient's foot with a blunt rod, the patient's toes curl. What is the response in this reflex action? Tick (✓) one box.

Correct answer: C
Explanation
One mark for the toes curling.
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Question #4
Muscle cells use oxygen for respiration. Explain why muscle cells need to respire.
Type your answer, then reveal.
Correct answer: To release energy for movement (e.g. muscle contraction).
Explanation
One mark for 'to release energy'. Do not accept energy is made, produced or created. One mark for 'for movement'. Also allow for muscle contraction, active transport, keeping warm, or muscle repair/growth.
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Question #5
Fatty material can build up in coronary arteries. The flow of blood through coronary arteries may be reduced. Which organ contains coronary arteries?
Type your answer, then reveal.
Correct answer: Heart
Explanation
Heart. Ignore heart muscle or cardiac muscle.
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Question #6
Fatty material can build up in coronary arteries. The flow of blood through coronary arteries may be reduced. There are different treatments for coronary diseases. Draw one line from each treatment to how the treatment works. Treatment: Replacement valve; Statin; Stent How the treatment works: Keeps coronary arteries open; Makes sure blood flows in one direction; Reduces blood cholesterol concentration; Reduces blood glucose concentration

Type your answer, then reveal.
Correct answer: Matching of treatments to how they work (three lines, one per treatment); stent = keeps coronary arteries open.
Explanation
One mark per correct line. Do not accept more than one line from a box on the left.
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Question #7
Some medical drugs can be produced using genetically modified (GM) bacteria. How are GM bacteria produced? Tick (✓) one box.
Correct answer: C
Explanation
One mark for genes being transferred into the bacteria.
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Question #8
What is one benefit of producing drugs using GM bacteria? Tick (✓) one box.
Correct answer: A
Explanation
One mark for the correct option.
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Question #9
Scientists are investigating the production of organs from GM animals for transplanting into humans. What is an advantage of using organs from GM animals compared with using organs from human donors? Tick (✓) one box.
Correct answer: A
Explanation
One mark for the correct option.
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Question #10
Scientists are investigating the production of organs from GM animals for transplanting into humans. Suggest one reason why some people disagree with the use of GM animals.
Type your answer, then reveal.
Correct answer: Any one: animals are killed; against religious beliefs; cruel; the animals may spread disease.
Explanation
Any one from the list. Also allow animals are hurt or harmed, or may not be safe for humans.
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Discussion
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